The S&P 500 Index closed down 64.99 points, a decrease of 0.94%, at 6816.63 points.

The Dow Jones Industrial Average closed down 403.51 points, a decrease of 0.83%, at 48,501.27 points. The Nasdaq Composite Index (Nasdaq) closed down 232.167 points, a decrease of 1.02%, at 22,516.691 points. The Nasdaq 100 Index closed down 272.516 points, a decrease of 1.09%, at 24,720.084 points. The Nasdaq Biotechnology Index closed down 2.28%, at 5,874.63 points. The Philadelphia Semiconductor Index closed down 4.58%, at 7,764.882 points. The Philadelphia Stock Exchange KBW Bank Index closed down 0.70%, at 158.96 points. The Dow Jones KBW Regional Bank Index closed down 0.81%, at 129.78 points.